Database : HANSEN Search on : ESPECIFICIDADE DE ESPECIES [Subject descriptor] References found : 15 [refine] Displaying: 1 .. 15   in format [Detailed]

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Id: 17554 Author: Young, Saroj K; Taylor, G. Michael; Jain, Suman; Suneetha, Lavanya M; Suneetha, Sujai; Lockwood, Diana N. J; Young, Douglas B Title: Microsatellite mapping of Mycobacterium leprae populations in infected humans ..- Source: s.l; s.n; Nov. 2004. 6 p. ilus, mapas, tab. Abstract: To investigate genetic diversity in a bacterial population, we measured the copy numbers of simple sequence repeats, or microsatellites, in Mycobacterium leprae from patients living in and around Hyderabad, India. Three microsatellite loci containing trinucleotide or dinucleotide repeats were amplified from infected tissues, and the copy numbers were established by sequence analysis. Extensive diversity was observed in a cross-sectional survey of 33 patients, but closely related profiles were found for members of a multicase family likely to share a common transmission source. Sampling of multiple tissues from single individuals demonstrated identical microsatellite profiles in the skin, nasal cavity, and bloodstream but revealed differences at one or more loci for M. leprae present in nerves. Microsatellite mapping of M. leprae represents a useful tool for tracking short transmission chains. Comparison of skin and nerve lesions suggests that the evolution of disease within an individual involves the expansion of multiple distinct subpopulations of M. leprae. (AU). Descriptors: Técnica de Tipagem Bacteriana/* Estudos Transversais Família Dosagem de Genes Hanseníase/EP/*MI/*TM Repetições de Microssatélites/*GE Mycobacterium leprae/*CL/*GE Reação em Cadeia da Polimerase Especificidade de Espécies Variação (Genética)/* Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09333/s

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Id: 17318 Author: Black, Gillian F; Weir, Rosemari E; Chaguluka, Steven D; Warndorff, David; Crampin, Amelia C; Mwaungulu, Lorren; Sichali, Lifted; Floyd, Sian; Bliss, Lyn; Jarman, Elizabeth; Docovan, Linda; Andersen, Peter; Britton, Warwick; Hewinson, Glyn; Huygen, Kris; Paulsen, Jean; Sing, Mahavir; Prestidge, Ross; Fine, Paul E. M; Dockrell, Hazel M Title: Gama interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-Mycobacterium bovis BCG-vaccinated Malawian young adults ..- Source: s.l; s.n; 2003. 10 p. graf. Abstract: We have previously shown that young adults living in a rural area of northern Malawi showed greater gamma interferon (IFN-gamma) responses to purified protein derivatives (PPD) prepared from environmental mycobacteria than to PPD from Mycobacterium tuberculosis. In order to define the mycobacterial species to which individuals living in a rural African population have been exposed and sensitized, we tested T-cell recognition of recombinant and purified antigens from M. tuberculosis (38 kDa, MPT64, and ESAT-6), M. bovis (MPB70), M. bovis BCG (Ag85), and M. leprae (65 kDa, 35 kDa, and 18 kDa) in >600 non-M. bovis BCG-vaccinated young adults in the Karonga District of northern Malawi. IFN-gamma was measured by enzyme-linked immunosorbent assay (ELISA) in day 6 supernatants of diluted whole-blood cultures. The recombinant M. leprae 35-kDa and 18-kDa and purified native M. bovis BCG Ag85 antigens induced the highest percentages of responders, though both leprosy and bovine tuberculosis are now rare in this population. The M. tuberculosis antigens ESAT-6 and MPT64 and the M. bovis antigen MPB70 induced the lowest percentages of responders. One of the subjects subsequently developed extrapulmonary tuberculosis; this individual had a 15-mm-diameter reaction to the Mantoux test and responded to M. tuberculosis PPD, Ag85, MPT64, and ESAT-6 but not to any of the leprosy antigens. We conclude that in this rural African population, exposure to M. tuberculosis or M. bovis is much less frequent than exposure to environmental mycobacteria such as M. avium, which have antigens homologous to the M. leprae 35-kDa and 18-kDa antigens. M. tuberculosis ESAT-6 showed the strongest association with the size of the Mantoux skin test induration, suggesting that among the three M. tuberculosis antigens tested it provided the best indication of exposure to, or infection with, M. tuberculosis. (AU). Descriptors: Antígenos de Bactérias/*IM Vacina BCG/*IM Interferon Tipo II/*BI Hanseníase/EP Malauí/EP Mycobacterium/GE/*IM Mycobacterium bovis/IM Mycobacterium leprae/IM Mycobacterium tuberculosis/IM Proteínas Recombinantes de Fusão/IM Especificidade de Espécies Linfócitos T/IM Teste Tuberculínico Tuberculose/IM Vacinação Limits: Adolescente Adulto Criança Estudo Comparativo Feminino Humano Masculino População Rural Location: BR191.1; 00224/s

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Id: 13485 Author: Kirchheimer, W. F; Sanchez, R. M Title: Intraspecies differences of resistance against leprosy in nine-banded armadillos ..- Source: s.l; s.n; oct. 1981. 6 p. tab. Abstract: Infection of nine-banded armadillos with decreasing doses of armadillo-passaged leprosy bacilli show that most individuals of this species are susceptible and only about 20 percent are resistant regardless of the size of the infecting bacterial dose. It is pointed out that the intraspecies distribution of resistance to leprosy in human beings and in nine-banded armadillos differs because most individuals of the former species are resistant. Attention is drawn to the possibility that the results of anti-leprosy vaccination in armadillos might not apply to vaccination of human beings because the differences in distribution of resistant individuals might also reflect different mechanisms of susceptibility in the two species.(AU). Descriptors: IMUNIDADE NATURAL HANSENIASE/imunol TATUS/imunol ESPECIFICIDADE DE ESPECIES XENARTROS/imunol Limits: ANIMAL MASCULINO FEMININO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00326/s

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Id: 13451 Author: Young, Douglas B; Khanolkar, Saroj R; Barg, Linda L; Buchanan, Thomas M Title: Generation and characterization of monoclonal antibodies to the phenolic glycolipid of Mycobacterium leprae ..- Source: s.l; s.n; jan. 1984. 6 p. ilus, tab, graf. Abstract: Nine cloned cell lines producing antibodies to the unique phenolic glycolipid of Mycobacterium leprae have been established as a result of fusions with spleens from mice immunized with the glycolipid complexed with methylated bovine serum albumin. One of the antibodies was relatively nonspecific, binding to a related glycolipid from Mycobacterium kansasii, but the remaining antibodies were specific for the M. leprae lipid. Some of the antibodies required the intact (trisaccharide) carbohydrate portion for recognition of the glycolipid antigen, whereas others recognized partially hydrolyzed forms lacking one or two sugar residues. Monoclonal antibodies directed at the terminal saccharide of the glycolipid showed the greatest specificity for M. leprae in enzyme-linked immunoassays. These antibodies brightly labeled whole mycobacteria in indirect immunofluorescence experiments, demonstrating the surface location of M. leprae-specific determinants of the glycolipid antigen. In addition to their use in providing information about the antigenic properties of the phenolic glycolipid, these antibodies have potential applications for elucidating the roles of glycolipid in the pathogenesis of leprosy.(AU). Descriptors: COMPLEXO ANTIGENO-ANTICORPO ELISA IMUNOFLUORESCÊNCIA GLICOLIPIDIOS/anal GLICOLIPIDIOS/imunol MYCOBACTERIUM LEPRAE CAMUNDONGOS ENDOGÂMICOS BALB C FENOIS PLASMOCITOMA/imunol ESPECIFICIDADE DE ESPECIES Limits: ESTUDO COMPARATIVO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01417/s

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Id: 11472 Author: Dockrell, Hazel M; Brahmbhatt, Shweta; Robertson, Brian D; Britton, Sven; Fruth, Uli; Gebre, Negussie; Hunegnaw, Mesfin; Hussain, Rabia; Manandhar, Rakesh; Murillo, Luis; Pessolani, Maria Cristina V; Roche, Paul; Salgado, Jorge L; Sampaio, Elizabeth; Shahid, Firdaus; Thole, Jelle E. R; Young, Douglas B Title: A postgenomic approach to identification of mycobacterium leprae-specific peptides as T-cell reagents ..- Source: s.l; s.n; 2000. 10 p. tab, graf. Descriptors: HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T GENOMA BACTERIANO ANTIGENOS HLA-DR ANTIGENOS HLA-DR TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PEPTIDIOS PEPTIDIOS ESPECIFICIDADE DE ESPÉCIES LINFOCITOS T Location: BR191.1; 08351/s

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Id: 11318 Author: Rastogi, Nalin; Goh, Khye Seng; Berchel, Mylene Title: Species-specific identification of mycobacterium leprae by PCR-restriction fragment length polymorphism analysis of the hsp65 gene ..- Source: s.l; s.n; 1999. 4 p. ilus, tab, graf. Descriptors: ALGORITMOS ANTIGENOS DE BACTÉRIAS TATUS CHAPERONINAS GENES ESTRUTURAIS BACTERIANOS HANSENIASE FIGADO GANGLIOS LINFATICOS CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS REAÇAO EM CADEIA POR POLIMERASE POLIMORFISMO DE FRAGMENTO DE RESTRIÇAO SENSIBILIDADE E ESPECIFICIDADE ESPECIFICIDADE DE ESPÉCIES BAÇO Location: BR191.1; 07257/s

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Id: 11025 Author: Ulrichs, T; Porcelli, S. A Title: CD1 proteins: targets of T cell recognition in innate and adaptive immunity ..- Source: s.l; s.n; 2000. 17 p. ilus, tab. Descriptors: FORMAÇAO DE ANTICORPOS APRESENTAÇAO DO ANTIGENO ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS CD1 ANTIGENOS CD1 ANTIGENOS CD1 ANTIGENOS CD1 EVOLUÇAO MOLECULAR GLICOLIPIDIOS GLICOLIPIDIOS IMUNIDADE NATURAL CÉLULAS KILLER NATURAIS HANSENIASE LIPIDIOS LIPIDIOS COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE MAMIFEROS MAMIFEROS CAMUNDONGOS MODELOS MOLECULARES MYCOBACTERIUM MYCOBACTERIUM CONFORMAÇAO PROTÉICA ESTRUTURA TERCIARIA DE PROTEINA RATOS RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA ESPECIFICIDADE DE ESPÉCIES SUB-POPULAÇOES DE LINFOCITOS T TUBERCULOSE Isoformas de Proteínas/CH/CL/GE/IM Limits: ANIMAL Location: BR191.1; 07486/s

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Id: 10171 Author: Richter, Elvira; Duchrow, Michael; Schluter, Carsten; Hahn, Margrit; Flad, Hans-D; Gerdes, Johannes Title: Detection of Mycobacterium leprae by three-primer PCR ..- Source: s.l; s.n; 1994. 3 p. ilus. Descriptors: SEQUENCIA DE BASES PRIMERS DO DNA ESTUDOS DE AVALIAÇAO HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE RNA BACTERIANO RNA RIBOSSOMICO 16S ESPECIFICIDADE DE ESPÉCIES Location: BR191.1; 07084/s

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Id: 9935 Author: Baelden, M. C; Bouckaert, A. E; Gregoire, D; Van de Poele, M; Coene, M Title: Comparison of thermostable macromolecular antigens from leprosy-associated bacteria ..- Source: s.l; s.n; 1994. 5 p. ilus, tab. Descriptors: HANSENIASE MYCOBACTERIUM MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE ANTICORPOS ANTIBACTÉRIAS ANTIGENOS DE BACTÉRIAS CORYNEBACTERIUM REAÇOES CRUZADAS ELISA IMUNOELETROFORESE ESPECIFICIDADE DE ESPÉCIES Location: BR191.1; 06856/s

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Id: 9799 Author: Sieling, P. A; Chatterjee, D; Porcelli, S. A; Prigozy, T. I; Mazzaccaro, R. J; Soriano, T; Bloom, B. R; Brenner, M. B; Kronenberg, M; Brennan, P. J; Modlin, R. L Title: CD1-restricted T cell recognition of microbial lipoglycan antigens ..- Source: s.l; s.n; 1995. 4 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE APRESENTAÇAO DO ANTIGENO CÉLULAS QUE APRESENTAM ANTIGENOS ANTIGENOS CD ANTIGENOS CD1 CONFIGURAÇAO DE CARBOIDRATOS SEQUENCIA DE CARBOIDRATOS LINHAGEM CELULAR INTERFERON TIPO II HANSENIASE LIPOPOLISSACARIDIOS TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR FOSFATIDILINOSITOIS RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA ESPECIFICIDADE DE ESPÉCIES LINFOCITOS T CITOTOXICOS Location: BR191.1; 06749/s

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Id: 9637 Author: Shaw, M. A; Atkinson, S; Dockrell, H; Hussain, R; Lins-Lainson, Z; Shaw, J; Ramos, F; Silveira, F; Mehdi, S. Q; Kaukab, F; Khaliq, S; Chiang, T; Blackwell, J Title: An RFLP map for 2q33-q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy ..- Source: s.l; s.n; 1993. 21 p. tab, graf. Descriptors: LINFOCITOS B SEQUENCIA DE BASES BRASIL LINHA CELULAR TRANSFORMADA SUSCETIBILIDADE A DOENÇA FREQUENCIA DOS GENES GENES MARCADORES GENÉTICOS LEISHMANIOSE LEISHMANIOSE HANSENIASE ESCORE LOD CAMUNDONGOS DADOS DE SEQUENCIA MOLECULAR LINHAGEM POLIMORFISMO DE FRAGMENTO DE RESTRIÇAO HOMOLOGIA DE SEQUENCIA DO ACIDO NUCLÉICO ESPECIFICIDADE DE ESPÉCIES TUBERCULOSE TUBERCULOSE Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 06555/s

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Id: 9621 Author: Launois, Pascal; N'Diaye, M'Bayame; Sarthou, Jean-Louis; Millan, Jacques; Bach, Marie-Anne Title: Anti-peripheral nerve antibodies in leprosy patients recognize an epitope shared by the M. leprae 65 kDa heat shock protein ..- Source: s.l; s.n; 1992. 13 p. ilus, tab. Descriptors: ANTICORPOS ANTIBACTÉRIAS ANTIGENOS DE BACTÉRIAS AUTO-ANTICORPOS AUTO-ANTIGENOS REAÇOES CRUZADAS EPITOPOS COBAIAS PROTEINAS DO CHOQUE TÉRMICO HANSENIASE CAMUNDONGOS MYCOBACTERIUM LEPRAE NERVOS PERIFÉRICOS COELHOS ESPECIFICIDADE DE ESPÉCIES IMUNOGLOBULINA G Limits: ANIMAL IN VITRO Location: BR191.1; 06571/s

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Id: 9341 Author: Arnoldi, J; Schluter, C; Duchrow, M; Hubner, L; Ernst, M; Teske, A; Flad, H. D; Gerdes, J; Bottger, E. C Title: Species-specific assessment of Mycobacterium leprae in skin biopsies by in situ hybridization and polymerase chain reaction ..- Source: s.l; s.n; 1992. 6 p. ilus, tab. Descriptors: SEQUENCIA DE BASES DNA BACTERIANO HANSENIASE LEPROMATOSA DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE HIBRIDIZAÇAO DE ACIDO NUCLÉICO REAÇAO EM CADEIA POR POLIMERASE PELE ESPECIFICIDADE DE ESPÉCIES Location: BR191.1; 06460/s

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Id: 9277 Author: Singh, Indira G; Mukherjee, Rama; Talwar, G. P Title: Resistance to intravenous inoculation of Mycobacterium tuberculosis H37Rv in mice of different inbred strains following immnunization with a leprosy vaccine based on Mycobacterium w ..- Source: s.l; s.n; 1991. 5 p. graf. Descriptors: VACINA BCG VACINA BCG INJEÇOES ENDOVENOSAS HANSENIASE CAMUNDONGOS CAMUNDONGOS DE CEPAS ENDOGAMICAS MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS ESPECIFICIDADE DE ESPÉCIES TUBERCULOSE Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 06242/s

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Id: 3763 Author: Turcotte, R; Ishaque, M Title: Impairment of virulence of in vitro subcultures of Mycobacterium lepraemurium ..- Source: s.l; s.n; 1983. 3 p. tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAEMURIUM MICOBACTERIOSE MICOBACTERIOSE TÉCNICAS BACTERIOLOGICAS MEIOS DE CULTURA CAMUNDONGOS ENDOGAMICOS C3H CAMUNDONGOS ENDOGAMICOS C57BL ESPECIFICIDADE DE ESPÉCIES VIRULENCIA Location: BR191.1; 02602/s

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